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2024
2023
2022
2021
2020
2019
B cells in autoimmune and neurodegenerative central nervous system diseases.
Sabatino JJ Jr, Pröbstel AK, Zamvil SS. Nat Rev Neurosci. 20(12):728-745. doi: 10.1038/s41583-019-0233-2. PMID: 31712781 (2019)
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10
Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, Burrows K, Robinson HG, Allanach JR, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne LC, Robbins C, Baranzini SE, Gommerman JL. Cell 176(3):610-624.e18. doi: 10.1016/j.cell.2018.11.035. PMID: 30612739; PMCID: PMC6903689 (2019)
Silent progression in disease activity-free relapsing multiple sclerosis
University of California, San Francisco MS-EPIC Team; Cree BAC, Hollenbach JA, Bove R, Kirkish G, Sacco S, Caverzasi E, Bischof A, Gundel T, Zhu AH, Papinutto N, Stern WA, Bevan C, Romeo A, Goodin DS, Gelfand JM, Graves J, Green AJ, Wilson MR, Zamvil SS, Zhao C, Gomez R, Ragan NR, Rush GQ, Barba P, Santaniello A, Baranzini SE, Oksenberg JR, Henry RG, Hauser SL. Ann Neurol 85(5):653-666. doi: 10.1002/ana.25463. PMID: 30851128; PMCID: PMC6518998. (2019)
Pröbstel AK, Zamvil SS. Ann Neurol 86(5):653-655. doi: 10.1002/ana.25584. PMID: 31531881; PMCID: PMC6856826. (2019)
Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis
Sabatino JJ Jr, Wilson MR, Calabresi PA, Hauser SL, Schneck JP, Zamvil SS. Proc Natl Acad Sci U S A 116(51):25800-25807. doi:10.1073/pnas.1915309116. PMID: 31748274; PMCID: PMC6926057. (2019)
2018
Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration
Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. Nat Immunol 19:1212-1223. doi: 10.1038/s41590-018-0232-x (2018)
T cells take aim at a ubiquitous autoantigen in multiple sclerosis
Sabatino JJ Jr, Zamvil SS.. Sci Transl Med 10: pii: eaau8826. doi: 10.1126/scitranslmed.aau882 (2018)
Häusler D, Häusser-Kinzel S, Feldmann L, Torke S, Lepennetier G, Bernard CCA, Zamvil SS, Brück W, Lehmann-Horn K, Weber MS. Proc Natl Acad Sci U S A 115:9773-9778. doi: 10.1073/pnas.1810470115 (2018)
The Evolving Mechanisms of Action of Glatiramer Acetate
Prod'homme T, Zamvil SS. Cold Spring Harb Perspect Med pii: a029249. doi: 10.1101/cshperspect.a029249 (2018)
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, Duan H, Ma P, Zhang L, Zamvil SS, Hidalgo J, Zhang Z, O'Rourke DM, Dahmane N, Brem S, Mou Y, Gong Y, Fan Y. Nat Commun 9:559. doi: 10.1038/s41467-018-03050-0 (2018)
B-Cell Therapies in Multiple Sclerosis
Sabatino JJ Jr., Zamvil SS, Hauser SL. Cold Spring Harb Perspect Med pii: a032037. doi: 10.1101/cshperspect.a032037 (2018)
The Gut Microbiome in Neuromyelitis Optica
Zamvil SS, Spencer CM, Baranzini SE, Cree BAC. Neurotherapeutics 15:92-101. doi: 10.1007/s13311-017-0594-z (2018)
2017
Aryl hydrocarbon receptor activity may serve as a surrogate marker for MS disease activity
Sabatino JJ Jr, Zamvil SS. Neurol Neuroimmunol Neuroinflamm 4:e366. doi: 10.1212/ NXI.0000000000000366 (2017)
Sagan SA, Cruz-Herranz A, Spencer CM, Ho PP, Steinman L, Green AJ, Sobel RA, Zamvil SS. J Vis Exp (126):56185 doi: 10.3791/56185 (2017)
Acute liver injury in a Glatopa-treated patient with MS
Sabatino JJ, Mehta NJ, Kakar S, Zamvil SS, Cree BAC. Neurol Neuroimmunol Neuroinflamm 4:e368 doi: 10.1212/ NXI.0000000000000368 (2017)
Cruz-Herranz A, Sagan SA, Sobel RA, Green AJ, Zamvil SS. J Nat Sci 3:e358 (2017)
2016
Sagan SA, Winger RC, Cruz-Herranz A, Nelson PA, Hagberg S, Miller CN, Spencer CM, Ho PP, Bennett JL, Levy M, Levin MH, Verkman AS, Steinman L, Green AJ, Anderson MS, Sobel RA, Zamvil SS. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1617859114 (2016)
B cell repertoire expansion occurs in meningeal ectopic lymphoid tissue
Lehmann-Horn K, Wang SZ, Sagan SA, Zamvil SS, von Büdingen HC. JCI Insight 1:e87234 (2016)
Treatment of spontaneous EAE by laquinimod reduces Tfh, B cell aggregates, and disease progression.
Varrin-Doyer M, Pekarek KL, Spencer CM, Bernard CCA, Sobel RA, Cree BAC, Schulze-Topphoff U, Zamvil SS. Neurol Neuroimmunol Neuroinflamm 3:e272. doi: 10.?1212/?NXI.?0000000000000272 (2016)
Mei F, Lehmann-Horn K, Shen YA, Rankin KA, Stebbins KJ, Lorrain DS, Pekarek K, A Sagan S, Xiao L, Teuscher C, von Büdingen HC, Wess J, Lawrence JJ, Green AJ, Fancy SP, Zamvil SS, Chan JR. Elife 5. pii: e18246. doi: 10.7554/eLife.18246 (2016)
Tremlett H, Fadrosh DW, Faruqi AA, Hart J, Roalstad S, Graves J, Spencer CM, Lynch SV, Zamvil SS, Waubant E; US Network of Pediatric MS Centers. BMC Neurol 16:182 (2016)
Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens.
Cree BA, Spencer CM, Varrin-Doyer M, Baranzini SE, Zamvil SS. Ann Neurol 80:443–447. doi: 10.1002/ana.24718 (2016)
Steinman L, Zamvil SS. Curr Opin Neurol 29:340-4. doi: 10.1097/WCO.0000000000000317 (2016)
Antibodies in multiple sclerosis oligoclonal bands target debris.
Winger RC, Zamvil SS. Proc Natl Acad Sci U S A 113:7696-8. doi: 10.1073/pnas.1609246113 (2016)
Your nose knows how to target brain inflammation.
Winger RC, Zamvil SS. Brain 139:1866-9. doi: 10.1093/brain/aww121 (2016)
Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2.
Schulze-Topphoff U, Varrin-Doyer M, Pekarek K, Spencer CM, Shetty A, Sagan SA, Cree BA, Sobel RA, Wipke BT, Steinman L, Scannevin RH, Zamvil SS. Proc Natl Acad Sci U S A 11:4777-82. doi: 10.1073/pnas.1603907113 (2016)
CNS accumulation of regulatory B cells is VLA-4-dependent.
Lehmann-Horn K, Sagan SA, Winger RC, Spencer CM, Bernard CC, Sobel RA, Zamvil SS. Neurol Neuroimmunol Neuroinflamm 3:e212. doi: 10.1212/NXI.0000000000000212 (2016)
2015
Glatiramer acetate treatment negatively regulates type I interferon signaling.
Molnarfi N, Prod'homme T, Schulze-Topphoff U, Spencer CM, Weber MS, Patarroyo JC, Lalive PH, Zamvil SS. Neurol Neuroimmunol Neuroinflamm 2:e179. doi: 10.1212/NXI.0000000000000179 (2015)
Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K. Nat Commun 6:8164. doi: 10.1038/ncomms9164 (2015)
Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A. Nat Immunol 16:618-27. doi: 10.1038/ni.3172 (2015)
Lehmann-Horn K, Sagan SA, Bernard CC, Sobel RA, Zamvil SS. Ann Neurol 77:902–908. doi: 10.1002/ana.24387 (2015)
Reduction of CD8+ T lymphocytes in multiple sclerosis patients treated with dimethyl fumarate.
Spencer CM, Crabtree-Hartman EC, Lehmann-Horn K, Cree BAC, Zamvil SS. Neurol Neuroimmunol Neuroinflamm 2:e76; doi: 10.1212/NXI.0000000000000076 (2015)
Zamvil SS, Slavin AJ. Neurol Neuroimmunol Neuroinflamm 2:e62. doi: 10.1212/NXI.0000000000000062 (2015)
2014
MOG transmembrane and cytoplasmic domains contain highly stimulatory T-cell epitopes in MS.
Varrin-Doyer M, Shetty A, Spencer CM, Schulze Topphoff U, Bernard CCA, Forsthuber T, Cree BAC, Slavin AJ, Zamvil SS. Neurol Neuroimmunol Neuroinflamm 1:e20; doi: 10.1212/NXI.0000000000000020 (2014)
Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE.
Shetty A, Gupta SG, Varrin-Doyer M, Weber MS, Prod'homme T, Molnarfi N, Ji N, Nelson PA, Patarroyo JC, Schulze-Topphoff U, Fogal SE, Forsthuber T, Sobel RA, Bernard CCA, Slavin AJ, Zamvil SS. Neurol Neuroimmunol Neuroinflamm 1:e22; doi: 10.1212/NXI.0000000000000022 (2014)
Laquinimod, an up-and-coming immunomodulatory agent for treatment of multiple sclerosis.
Varrin-Doyer M, Zamvil SS, Schulze-Topphoff U. Exp Neurol pii: S0014-4886(14)00097-1. doi: 10.1016/j.expneurol.2014.04.002 (2014)
Weber MS, Prod'homme T, Youssef S, Dunn SE, Steinman L, Zamvil SS. J Neuroinflammation 11:29 (2014)
2013
Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CC, Shlomchik MJ, Zamvil SS. J Exp Med 210:2921-37 (2013)
Therapeutic Decisions in Multiple Sclerosis: Moving Beyond Efficacy.
Brück W, Gold R, Lund BT, Oreja-Guevara C, Prat A, Spencer CM, Steinman L, Tintoré M, Vollmer TL, Weber MS, Weiner LP, Ziemssen T, Zamvil SS. JAMA Neurol doi: 10.1001/jamaneurol.2013.3510 (2013)
Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity.
Schulze-Topphoff U, Casazza S, Varrin-Doyer M, Michel K, Sobel RA, Hauser SL, Oksenberg JR, Zamvil SS, Baranzini SE. J Exp Med 210:1301-09 (2013)
2012
Varrin-Doyer M, Spencer CM, Schulze-Topphoff U, Nelson PA, Stroud RM, Cree BAC, Zamvil SS. Ann Neurol 72:53-64 (2012)
Schulze-Topphoff U, Shetty A, Varrin-Doyer M, Molnarfi N, Sagan SA, Sobel RA, Nelson PA, Zamvil SS. PLoS One 7:e33797 (2012)
Randomized controlled trial of atorvastatin in clinically isolated syndrome: the STAyCIS study.
Waubant E, Pelletier D, Mass M, Cohen JA, Kita M, Cross A, Bar-Or A, Vollmer T, Racke M, Stüve O, Schwid S, Goodman A, Kachuck N, Preiningerova J, Weinstock-Guttman B, Calabresi PA, Miller A, Mokhtarani M, Iklé D, Murphy S, Kopetskie H, Ding L, Rosenberg E, Spencer C, Zamvil SS; ITN STAyCIS Study Group; ITN020AI Study Management Team. Neurology 78:1171-8 (2012)
2011
B cells in multiple sclerosis: connecting the dots.
Von Büdingen HC, Bar-Or A, Zamvil SS. Curr Opin Immunol 23:713-20 (2011)
Zamvil SS, Steinman L. Lancet Neurol 10:672-3 (2011)
2010
Nelson PA, Khodadoust M, Prodhomme T, Spencer C, Patarroyo JC, Varrin-Doyer M, Ho JD, Stroud RM, Zamvil SS. PLoS One 5:e15050 (2010)
Weber MS, Prod'homme T, Patarroyo JC, Molnarfi N, Karnezis T, Lehmann-Horn K, Danilenko DM, Eastham-Anderson J, Slavin AJ, Linington C, Bernard CC, Martin F, Zamvil SS. Ann Neurol 68:369-83 (2010)
2008
Bench to Bedside: Tempering antigen-presenting cells in multiple sclerosis.
Prod'homme T, Zamvil SS. Nat Med 14:614-615 (2008)
2007
Type II monocytes modulate T cell-mediated central nervous system autoimmune disease.
Weber MS, Prod'homme T, Youssef S, Dunn SE, Rundle CD, Lee L, Patarroyo JC, Stüve O, Sobel RA, Steinman L, Zamvil SS. Nat Med 13:935-943 (2007)
T effectors outfox T regulators in autoimmunity.
Prod'homme T, Weber MS, Zamvil SS. Nat Med 13:411-413 (2007)
2006
Stuve O, Youssef S, Weber MS, Nessler S, von Budingen HC, Hemmer B, Prod'homme T, Sobel RA, Steinman L, Zamvil SS. J Clin Invest 116:1037-1044 (2006)
Dunn SE, Youssef S, Goldstein MJ, Prod'homme T, Weber MS, Zamvil SS, Steinman L. J Exp Med 203:401-412 (2006)
Zamvil SS, Steinman L. Ann Neurol 60:12-21 (2006)
Statin therapy and autoimmune disease: from protein prenylation to immunomodulation.
Greenwood J, Steinman L, Zamvil SS. Nat Rev Immunol 6:358-370 (2006)
A neuropeptide in immune-mediated inflammation, Y?
Prod'homme T, Weber MS, Steinman L, Zamvil SS. Trends Immunol 27:164-178 (2006)
2005
Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis.
Steinman L, Zamvil SS. Trends Immunol 26:565-571 (2005)
2003
Zamvil SS, Steinman L. Neuron 38:685-688 (2003)
Transcriptional analysis of targets in multiple sclerosis.
Zamvil SS, Steinman L. Nat Rev Immunol 3:483-492 (2003)
2002
Youssef S, Stuve O, Patarroyo JC, Ruiz PJ, Radosevich JL, Hur EM, Bravo M, Mitchell DJ, Sobel RA, Steinman L, Zamvil SS. Nature 420:78-84 (2002)
Stuve O, Youssef S, Slavin AJ, King CL, Patarroyo JC, Hirschberg DL, Brickey WJ, Soos JM, Piskurich JF, Chapman HA, Zamvil SS. J Immunol 169:6720-6732 (2002)
Patarroyo JC, Stuve O, Piskurich JF, Hauser SL, Oksenberg JR, Zamvil SS. Genes and Immunity 3:34-37 (2002)
2001
Slavin AJ, Soos JM, Stuve O, Patarroyo JC, Weiner HL, Fontana A, Bikoff EK, Zamvil SS. J Clin Invest 108:1133-1139 (2001)